Why didn’t the person that died just not die? Are they stupid?

• A person who was not there and did nothing to help

The amyloid hypothesis has been supported by fraud for 20 years.

Pharma made drugs that dropped amyloid by 30% and they do NOTHING despite FDA approvals.

Okay, got any sources for that, or should we take you at your word?

Mouse models do not get dementia.

I don’t believe I said they did. Why the confrontational tone?

Misleading headline. What they actually demonstrated is reversing amyloid accumulation and the cognitive deficits in a transgenic mouse whose pathology is essentially just amyloid accumulation. Calling that “reversing Alzheimer’s” treats amyloid buildup and the disease as the same thing, which is exactly the conflation the amyloid hypothesis has been criticised for over the last decade.

Alzheimer’s in humans is amyloid + tau tangles + neuroinflammation + vascular dysfunction + actual neurodegeneration (entorhinal and hippocampal neurons dying, brain volume measurably dropping on MRI). Tau burden correlates with cognitive decline far better than amyloid does. The IBEC paper addresses one of those layers, the upstream-ish one, in a model that doesn’t reproduce most of the others. Fixing a cause in a young system before damage has accumulated is just not the same operation as fixing an established disease in an old human cortex that’s already lost the cells.

The human translation data backs this up. Lecanemab clears plaques and slows cognitive decline by about 27% over 18 months. Donanemab clears around 76% of plaques and slows decline by ~35% in early AD. In both trials both arms still declined, treatment just declined a bit more slowly. Northwestern’s Mesulam Institute puts it bluntly: “These medications do not reverse existing disease or stop the progression.” So removing amyloid in a system that already has the full human pathology bends the curve, it doesn’t undo anything.

What the IBEC team has here is a genuinely interesting result for the cerebrovascular angle, where BBB dysfunction and glymphatic clearance failure are upstream of plaque accumulation rather than a downstream consequence. The LRP1 transport mechanism and the multivalent ligand design are clever and well-grounded. The fair claim is “we improved amyloid clearance and rescued behavioural deficits in an amyloid-overexpressing mouse by targeting BBB transport.” That’s a real contribution. “Reversed Alzheimer’s” sells the mechanism by overstating what it did, and it sets up the same disappointment cycle the field has been through with every other anti-amyloid intervention that worked great in mice.

Original paper, for anyone wanting the actual data: https://doi.org/10.1038/s41392-025-02426-1

I only made one citation in my comment and the source was the propaganda of the DPRK itself. You may want to check again who you’re responding to because you seem confused.

Cool story. North Korea is so dystopian they put out a film called “A Day In The Life”: https://www.themoviedb.org/movie/47357-noord-korea-een-dag-uit-het-leven

And, even though this is their “best foot forward”, it makes the whole country look like what the rest of us would consider a goddamn prison camp. The stories about North Korea are insane, but they are accurate.

but I feel like what the 박연미 types are saying are either exaggerated or false, as the south and US think tanks pays them to come up with the most insane story

Only an idiot would shill for brutal dictatorships like this, ignoring all available evidence in favour of their feelings. Congratulations, you’re a Donald Trump voter.

I’m so fucking confused, man. I’m a tech guy. I’ve spent my whole life getting good with computers, I know very little about cars, and I just can’t keep up. I’ve heard that yeah ethanol is bad but put in your tank what the manual says because if your engine isn’t designed for “high-octane” fuel (???) you’ll damage your car with the pure stuff? But I know how ethanol dries out rubber, which I’m quite sure is what my fuel lines are made of, but my manual says to use 85. So should I be using 87 and avoiding 85? Or…?

I just want an electric car. “Plug it in”, I get.

Edit: Thank you to everyone who responded! It was salient as I was actually driving at the time and saw the comments before my next stop; I ended up getting the right gas thanks to you all. My car immediately started running better. I’m a lot less confused now, I’ll be using 87 gas from now on. Thankfully my car seems to have survived my mistake(s) without any immediately negative consequences >.>

Fuck yeah. Who doesn’t like good news? 🎉 Also, really surprised they got it working well enough on RDNA 2 to plan to release it, that’s just gravy on the cake.

Aw, I understand, you’ve had your warm milk and now it’s nap time. Kiddos need their sleep!

The protests have grown by a million people with every event, give or take. They show the people who have a problem with this shit that they’re not alone, and more and more people have a problem with all this. The protests show the people in power right now that we are not going to lay down and take it, like you lot want to keep saying we are.

And, what does protesting actually accomplish? In Nazi Germany, it got 1,800 Jewish prisoners released: https://en.wikipedia.org/wiki/Rosenstrasse_protest

So if you really want these fuckers gone as badly as the rest of us, how about you take your defeatist crap and keep it at home with you? It’s not helping anyone except the fascists.

Or you could stop doing the work of the fascists, but I think you like the kool-aid too much for that. Feels good talking down to people being killed for resisting, does it? You’re as bad as the people you claim to hate, you just can’t see it.

Don’t worry, most people grow into empathy eventually, we all develop at different rates.

Yes, collateral damage is to be expected when a superpower gets destabilised. Why are you ignoring the fact that there was documented election interference on a massive scale? Why are you ignoring the total takeover of our government by hostile actors? Are you trying to paper over all of that for some particular purpose?

Moreover, you’re mostly addressing the victims of the fascists here. We’re not actually in charge of the country right now.

Very, very interesting that you’re advocating for civil war. I wonder whose interests that could possibly serve.

Earth Day, 1970, 20 million. Latest No Kings was 8 million. But still, No Kings accounts for 3 of the top 4.

As to starting earlier, you said yourself it’s a logistical nightmare. I would argue people got organised PDQ, all things considered.

Right, lay down. That’s what some of the largest protests in united states’ history are. Protests that are getting larger by the month. “Laying down”.

You aren’t in any position to criticise, keyboard warrior.

“Both” is also acceptable.

I am not patronising and that was not my intent. Read whatever you want into it of course, I can’t stop you.

Well, sure, and I appreciate your sanguinity haha! I just main support, and felt your question deserves a proper answer.

I am planning on answering when I’m at a computer, as well, because I actually do have a matrix server set up with Synapse and MAS. Quick question though, when you ask how it works, do you mean the actual backend, or are you asking if the performance/user experience is good?

Don’t get me wrong, suggestions are appreciated, but you’re answer is absolutely typical of a Stack overflow “huhuh well don’t do it wrong then” comment. You could have, for example, said you don’t use Synapse but this is why you like Continuwuity. (edit: not prescribing speech, giving an example of how your comment could have read better)

As well, I take issue with the idea that people can only ask for help in sanctioned forums. This is a self-hosting community, after all; I am here not only to learn but to share what I learn, which I thought was the whole point.

What is this, StackOverflow? You didn’t answer their question and instead just told them to use a different solution.

That gesture from panel 3 is my squid impression! Probably one of the best dad jokes I have, almost always gets at least a little smile.